Lee Fleisher, MD, ML, is co-founder and CEO of Rubrum Advising and a nationally recognized healthcare leader whose work bridges clinical practice, health policy, and the adoption of innovative care models.

From 2020 to 2023, Lee served as Chief Medical Officer and Director of the Center for Clinical Standards and Quality (CCSQ) at the Centers for Medicare & Medicaid Services (CMS). Before joining CMS, he was Chair of Anesthesiology and Critical Care at the University of Pennsylvania, where he remains Professor Emeritus and a practicing anesthesiologist. At CMS, Lee was responsible for national clinical, quality, and safety standards for healthcare facilities and providers, as well as Medicare coverage determinations for items and services that improve health outcomes. As a member of the CMS and HHS executive leadership team, he helped shape federal responses to public health emergencies, including COVID-19 and MPOX, and worked closely with clinical, regulatory, and operational leaders across the healthcare system. 

In 2023, Lee co-founded Rubrum Advising to help advance transformative care through integrated clinical, regulatory, and commercial strategies and solutions—with a goal of accelerating adoption so people receive better care, sooner. In addition to leading the firm, he advises clients on building evidence strategy, regulatory and reimbursement pathways, and the operational realities that determine whether innovation succeeds in practice. 

Lee is a member of the National Academy of Medicine and the Health Information Technology Advisory Committee (HITAC). He serves as a senior advisor and visiting fellow at leading health policy centers, including the Duke Margolis Institute for Health Policy, the Bipartisan Policy Center, and the Milken Institute FasterCures.